Spinal cord injury treatment in India

NeuroGen’s unwavering distinctiveness lies in its ability to combine seamlessly, the newest developments (stem cells) with conventional, tried and tested rehabilitation techniques. The amalgamation of the new and the old in the form of synergistic teamwork, all under one roof, enables our patients to hope, in an otherwise despondent condition, for the possibility of a better quality of life.

Some time ago donated organs were transplanted to replace the diseased or failed organs in the recipients. Soon the number of recipients exceeded the number of donated. To overcome this demand, cell therapy offered the possibility of replacement of the damaged cells of tissue with new cells. Stem cell infusion helps to treat a plethora of conditions including cerebral palsy, spinal cord injury, intellectual disability, and other neurodegenerative syndromes as well.

Stem cells have the potential to develop into different cells of the tissues (of the body) and the ability of self-renewal. When serving as a repair system, the stem cells divide without limit as long as the person is alive. As they divide, they remain as stem cells or develop into cells with more specialized functions, like a brain cell or a muscle cell.

Stem cells, from different sources, have three common properties: They can grow into specialized cell types such as nerve cells, muscle cells, and blood cells.

Impairments linked to neuromuscular conditions are usually irreversible due to inadequate cell regeneration or impaired cells in the central nervous system. It was observed that the cellular characteristics of autologous stem cells had the capability of treating major neurological disorders without incurring any side effects. With their neurotrophic properties, self-renewal & differentiation capacity, and immune modulation effects, the bone marrow-derived stem cells are considered as a promising candidate for treating disorders related to the nervous system.

For cell treatment, bone marrow derived mesenchymal stem cells are isolated from the marrow tissue (extracted from the patient’s hip bone) in an expedited, painless and safe way. By centrifugation procedure, a sufficient number of stem cells are separated from the unwanted tissue within a few hours. These injectable stem cells are infused intrathecally into the spinal area or the damaged muscle points, as per the need of the patients.

These bone marrow-derived stem cells have many useful properties that lead to great clinical improvement in post-cell-based therapy. According to various clinical trials, treatment with bone marrow derived mesenchymal stem cells have shown improvement in patients with traumatic brain injury, spinal cord injury and other neurological disorders through axonal sprouting and remyelination, potential to replace/protect the damaged neurons/cells, and neovascularization.

How do the infused stem cells act? Once infused into the body,

– The infused stem cells journey toward the nervous system and blend into the neural circuits to mend or improve the disrupted synaptic transmission.
– Post infusion, improved neuropathological condition, upregulated Aß clearance and reduced deposition is detected within a short period.
– The infused stem cells reduce neuroinflammation and provide protective immunomodulatory effect.
– The stem cells secrete neurotrophic influence and nerve growth factors, bringing cognitive and memory improvement in patients.

Apart from encouraging effects, renewed brain plasticity is also observed in patients following intrathecal delivery of stem cells. With the new medical breakthrough in stem cell therapy, the treatment has become a highly sought-after curative. To know about the treatment efficacy, one must understand the efficiency of stem cells in terms of engraftment, migration, cytokines and growth factors. However, cell-based therapy is a promising contribution to regenerative medicine and has gained considerable clinical attention. Read more info at https://www.neurogenbsi.com.

Considerations Before Starting Treatment: The needs of a child with cerebral palsy aren’t solely based on correcting their physical disabilities. There are also social and emotional aspects of living a more fulfilling life. These aspects shouldn’t be ignored when considering treatment and therapy. Many children are content with their disabilities. As a parent, it’s important to consider their feelings. Some treatments can be stressful and uncomfortable, and may not be in the best interest of the child. It’s important to discuss the physical and emotional impacts of all treatments with specialists and most importantly, the child.

A few tips to help your child with autism: Stick to a schedule. Children with ASD tend to do best when they have a highly-structured schedule or routine. Again, this goes back to the consistency they both need and crave. Set up a schedule for your child, with regular times for meals, therapy, school, and bedtime. Try to keep disruptions to this routine to a minimum. If there is an unavoidable schedule change, prepare your child for it in advance. Reward good behavior. Positive reinforcement can go a long way with children with ASD, so make an effort to “catch them doing something good.” Praise them when they act appropriately or learn a new skill, being very specific about what behavior they’re being praised for. Also look for other ways to reward them for good behavior, such as giving them a sticker or letting them play with a favorite toy.

What’s the long-term outlook? Some people lead full and productive lives after a spinal cord injury. However, there are severe potential effects of a spinal cord injury. The vast majority of people will need assistive devices such as walkers or wheelchairs to deal with loss of mobility, and some may even be paralyzed from the neck down. You may need assistance with daily living activities and learn to perform tasks differently. Pressure sores and urinary tract infections are common complications. You also may expect to undergo intense rehabilitation treatment for your spinal cord injury.

US researchers are now trying to find a way to use stem cells for patients with paralysis or brain injury, for patients with type 1 diabetes, those with spinal cord injury, heart disease, people who have a heart attack or disorder neurological disorders such as multiple sclerosis. Many of the studies have been carried out on animals, and the results are in an early stage. It is important to note that the treatment with stem cells is not done with the patient’s own stem cells, because this is how the premises of the disease return are created. However, there were exceptions, proof stands a case from 2007, published in the journal Pediatric, of a child who was ill with leukemia and who was transplanted his own stem cells harvested at birth, following that 5 years after the intervention, the child to be completely healthy. Instead, it is indicated that the stem cell donors are the patient’s brother or sister. But in only 25% of cases it is shown that the brother is compatible with the patient, and 7 out of 10 patients must seek a donor outside the family.

The spinal cord is the chief line of the nerve tissues that give rise to the spinal nerves. They connect the brain and the vertebral canal to the rest of the body. A spinal cord injury, disrupts this connection. Defects in the sensory, motor and reflex messages, are detected after a spinal cord injury. After such a trauma, a person may not be able to function properly and the condition could worsen when the level of injury is higher. A cervical spinal cord injury involves the loss of movement & function in all four limbs. Quadriplegia involves the arms, legs, hands and pelvis after a cervical spinal cord injury. The spinal cord injury symptoms associated with a cervical spinal cord injury are difficulty in respiration, loss of bladder & bowel movement, loss of limb function. Due to prolonged lackof movement, this type of spinal cord injury increases the chances of bedsores, or decubitus ulcers. See more info Stem Cell Treatment For Spinal Cord Injury.